Fly to the beautiful colonial city of Arequipa, Peru’s second-largest city at 7,660ft, perfect for acclimatizing. Surrounded by three volcanoes, Arequipa’s buildings are crafted from volcanic rock. After breakfast, enjoy a tour starting at Carmen Alto viewpoint, offering stunning views. Explore the Yanahuara quarter with its cobbled streets and baroque church, then visit Arequipa’s UNESCO-listed historic center, Plaza de Armas, and the grand 17th-century La Compañía church. End the day at the Monastery of Santa Catalina, founded in 1580.